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Our Research

Our research is dedicated to understanding the impact of genes on specific traits by developing robust genome sequencing data analysis methods, including our unique "Genomics Analysis and Annotation Pipeline." This pipeline integrates bioinformatics, statistical genomics, and population genetics. Additionally, we are enhancing our research by applying machine learning techniques and utilizing variant-, gene-, or pathway-based modeling and network simulations, leveraging our expertise in genetics, bioinformatics, and statistical analysis.

Our primary goals involve developing rapid analytic approaches using machine learning computational techniques to analyze exome/genome sequencing data, enabling large-scale discovery of rare mutations and aiding in the development of diagnostic tools for Mendelian disorders. Furthermore, we aim to identify genes with incomplete penetrance to better understand genetic factors contributing to complex traits and diseases. Additionally, we seek to pinpoint population-specific disease-causing mutations, genes, and pathways, leading to more tailored diagnosis and treatment strategies.

Our research focuses on advancing genomics through innovative analytical approaches and cutting-edge technologies to unravel the complex relationships between genes, traits, and diseases, ultimately improving human health management. At the ONAT Lab, we explore a wide range of rare and complex diseases, including metabolic disorders, neurodegenerative disorders, and behavioral/psychiatric disorders. We utilize state-of-the-art omics technologies to investigate disease mechanisms, identify disease genes, predict patient outcomes, and develop therapeutic strategies, with a particular focus on integrating and analyzing multi-omics data.

Collaboration is central to our research, and we collaborate with leading scientists worldwide, including Nobel laureates and professors from prestigious institutions. Our interdisciplinary research group focuses on unraveling the determinants and pathogenesis of human diseases through innovative strategies and reproducible "Genomics Pipelines." Overall, our work at the ONAT Lab holds significant promise for improving our understanding of human diseases and developing new treatments across various disorders.





The lab's research has been funded by the The Scientific and Technological Research Council of Türkiye (TÜBİTAK), Bezmialem Vakıf University (Startup), Transatlantic Networks of Excellence (Brown Fat and Cardiovascular Health Network), and HHMI (Rockefeller University Center for Clinical and Translational Science (RUCCTS).

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